Testosterone Therapy May Have Benefits, but Risks Too
00:22, Feb 25, 2017
Copyright 2015 All rights reserved. This material can't be published, transferred, copied or redistributed.
The research was not created to look at risks and does not apply to younger men or those with normal levels of testosterone, said study leader Dr. Peter Snyder, a University of Pennsylvania hormone specialist. It found a 20% increase in arterial plaque among men aged 65 and older who received testosterone replacement therapy for a year, according to the study published today in the Journal of the American Medical Association (JAMA).
The Testosterone Trials were supported by grants from the National Institute on Aging; the National Heart, Lung, and Blood Institute; the National Institute of Neurological Diseases and Stroke; and the National Institute of Child Health and Human Development.
"The paper reporting the results of the first three trials published previous year was the first to show there were advantages to giving testosterone treatment to older men with low testosterone levels, and the bone and anemia trial results further support a benefit".
On the positive side, testosterone therapy significantly increased bone density in 211 men and corrected anemia in 126 men by increasing hemoglobin levels.
The hazard ratios similarly favored testosterone therapy for stroke and TIA and for the cardiac events separately, T. Craig Cheetham, PharmD, of the Southern California Permanente Medical Group in Pasadena, reported in JAMA Internal Medicine. The goal was to see if rubbing testosterone gel on the skin daily for a year could treat problems linked with low levels of the male hormone, which declines with age. Four of them delved on the effects on anemia, bone density, cognitive function, as well as coronary plaque buildup.
"Our study finds benefits of testosterone treatment in improving bone density and anaemia".
"Testosterone and synthetic androgens have valuable medical applications but a key lesson is that such novel indications should be established by efficacy and safety studies and not preceded by wide-scale, off-label adoption", he wrote.
The participants were then randomly divided into two groups: one group took a daily dose of testosterone in the form of a gel for a year, while the other group took placebo for the same period of time.
Senior author Dr. Peter Snyder said that TTrials were created to investigate testosterone therapy's effectiveness rather than risk, apart from the fact that they did not address long-term consequences.
Low testosterone has been linked with everything from erectile disorder to prostate cancer to general fatigue, but most experts recommend seeking a doctor's advice before you supplement - especially if you don't have low T to begin with.
Study Rundown: Decrease in serum testosterone commonly occurs in elderly men.
A third study found no association between testosterone supplementation and memory improvement. But it may also make artery disease worse.
Overall plaque volume and coronary artery calcification scores by CT angiography were similar between groups in their study within the Testosterone Trials ("T Trials"), the first of which showed an increase in libido but not vitality.
"The results on diverse outcomes indicate the potential trade-offs between benefits and risks of testosterone treatment in older men", Evan Hadley, MD, director of National Institute on Aging's Division of Geriatrics and Clinical Gerontology, said in a press release from the NIH. The Bone Trial included 189 of the 790 men in the overall study. AbbVie (formerly Solvay and Abbott Laboratories) also provided funding, AndroGel, and placebo gel. So longer, bigger trials will be needed to sort out the risks.
SHALENDER BHASIN: The frail elderly or people who have preexisting heart disease or have had a recent heart attack or a stroke - I think one should be particularly careful in those individuals.
On the contrary, it was identified that after one year of use, an estimate of 140 men who had used the real thing had shown more plaque buildup. They weigh the available evidence and individualize their treatment decisions and have that conversation with their patients about the uncertainty, about the risks and benefits.
In December, the court said that prosecutors had not made a sufficient case for Lee's detention, an interim victory for Samsung. Although Jay Lee was arrested and might be convicted, it is unlikely he will serve jail time for very long - if at all.
After progressing to the quarter-finals of the FA Cup , Chelsea now look well on course to complete a domestic double. Pedro plants a lovely header in at the near post after sneaking in behind Edwards to meet Willian's lovely cross.
After 12 years, the Georgia Bureau of Investigation has a break in beauty queen, Tara Grinstead's disappearance. A website, findtara.com , provided information about her disappearance and investigators' contact information.
Mattis told reporters that USA rules of engagement in the fight against ISIS will not be changed from the Obama administration's. Mattis remarks are only the latest example of his policy differences with Trump. "Maybe we'll have another chance".
The daughter of Elvis Presley is accusing her ex-husband of storing disturbing photos and videos of children on his computer. The court papers also state pending allegations of sexual abuse and neglect on the part of Michael.
And she's been throwing herself back into work and is looking forward to getting out on the road around the world later this year. She added to "Entertainment Tonight": "My oldest, 16, is not the man of the house [because] you have to have your own dreams.
Kinberg reportedly wrote a script for a new X-Men film a year ago , presumably as a follow-up to X-Men: Apocalypse . All the project seemed to need was a director and writer/producer Simon Kinberg came in as a flawless fit.
Aguero is a great player but he takes too many touches for Pep Guardiola and doesn't work hard enough to close people down. They have to play Liverpool at home four days after that game and then they go to Arsenal and Chelsea.
After trashing Browne and courting Ronda Rousey post-fight, Lewis' unpredictability has instantly become must-see TV, too. What could be worse than getting knocked out? "It's not really hurting from the kick, I've just got to boo-boo".
An Israeli soldier has been sentenced to 18 months in prison for killing an incapacitated Palestinian attacker previous year . The soldier's father, Charlie, thanked the protesters and urged them to remain calm.
7 things to know about those $65 fares to Europe
There's been a wide-ranging welcome for the announcement of two new low cost services from Shannon to the USA this summer. In the end, however, the outgoing Obama administration cleared the application. "These new flights are a starting point".
Men TV Series Gets Blink
As we reported a year ago , the untitled series follows two ordinary parents who discover their kids have mutant powers. Chung, according to JoBlo , will play Blink , a "sardonic and spirited mutant with the power of teleportation ".
Pruitt Emails Show Ties With Fossil Fuel Players
His only reference of the "toxic environment" was related to politics, and how it damaged compromise. Pruitt also addressed his views about regulation: "Regulations ought to make things regular".
FBI Not Expected To Pursue Charges Against Michael Flynn
Spicer later says the call was "centered on the logistics of setting up a call" between Trump and President Vladimir Putin. Flynn was interviewed by the FBI around the same time , according to a USA official who was briefed on the investigation.
Bodies of drowned refugees found on Libya's shores
The Red Crescent's branch in Zawiya said there are bodies still floating out at sea but it has no means to retrieve them. The bodies of 74 drowned migrants have washed ashore from the Mediterranean in Libya, aid workers have said .
Adele sweeps Grammy Awards with 5 wins
Fans feared the very-pregnant songstress wouldn't be able to deliver her usual high caliber performance during the award show. During her acceptance speech, Adele tearfully said that she was dedicating the Album of the Year award to Beyonce.